Links to PubMed are also available for Selected References. These references are in PubMed. This may not be the complete list of references from this article. National Center for Biotechnology Information , U. Yale J Biol Med. Copyright and License information Disclaimer. Rarely, Addison disease is not caused by an autoimmune reaction.
Other causes include infections that damage the adrenal glands, such as tuberculosis, or tumors in the adrenal glands. Addison disease can also be one of several features of other genetic conditions, including X-linked adrenoleukodystrophy and autoimmune polyglandular syndrome, type 1, which are caused by mutations in other genes. A predisposition to develop autoimmune Addison disease is passed through generations in families, but the inheritance pattern is unknown.
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Autoimmune Addison disease. From Genetics Home Reference. Description Autoimmune Addison disease affects the function of the adrenal glands, which are small hormone-producing glands located on top of each kidney. Frequency Addison disease affects approximately 11 to 14 in , people of European descent. Causes The cause of autoimmune Addison disease is complex and not completely understood.
Inheritance A predisposition to develop autoimmune Addison disease is passed through generations in families, but the inheritance pattern is unknown. Conclusions: New-onset eosinophilia may be a useful marker for adrenal insufficiency. Prompt testing and diagnosis may avoid the occurrence of a treatable, life-threatening condition. Background Adequate adrenocortical function is essential to survive critical illness.
Methods During a 1-year period, we studied prospectively all patients admitted to our ICU. Results The mean age was Conclusion Relative eosinophilia may be considered a useful and early bioassay for adrenocortical function assessment in critically ill patients with severe septic shock and assumed adrenocortical depression.
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